El miércoles 19 de julio a las 14 horas en el Salón del Claustro se llevará a cabo el seminario "Solvated Nickel Complexes as Stoichiometric and Catalytic Trifluoromethylation Agents", dictado por David A. Vicic de la Lehigh University de Estados Unidos.
La actividad es de carácter obligatorio para los estudiantes de posgrado del departamento de Química Orgánica y está abierta al público general.
Abstract: Simple fluorinated functional groups play important roles in the life sciences and materials fields, as well as in discovery chemistry in general. For example, the percentage of fluorinated pharmaceuticals among the total number of registered synthetic drugs is extraordinary (51% in 2018 and 43% in 2019). Likewise, the percentage of fluorinated agrichemicals is equally impressive (53% from 1998 to 2020).2 As such, the development of more effective strategies to introduce fluorinated groups into organic substrates is a high priority in chemical synthesis. I will outline the challenges of introducing even simple fluorinated groups into organic substrates and present strategies to develop practical trifluoromethylation and fluoroalkylation strategies at a first-row metal like nickel. The possibility to perform challenging fluoroalkylation reactions using only solvent as the supporting ligands will be discussed as will the fundamental organometallic chemistry that is operative in many of these reactions.